Reviewed safety lookup · substance

Half-Life Calculator
Psilocybin / psilocin.

Psilocybin / psilocin is applied as the substance context, but no half-life number is invented. The user must supply an exact product- or molecule-specific source before the mathematical model can be treated as more than an illustration.

Evidence modesafety boundaryPsilocybin / psilocin is applied to the real calculator input; unconfirmed high-risk values remain unconfirmed.
Value-level evidence

Psilocybin / psilocin profile

Reviewed 2026-08-28

Psilocybin / psilocin is applied as the substance context, but no half-life number is invented. The user must supply an exact product- or molecule-specific source before the mathematical model can be treated as more than an illustration.

  • Psilocybin is converted to psilocin; the compound named by the source must match the model input.
  • Profile type: analyte; the preset remains explicitly unverified and is not a dosing, driving, procedure or testing clearance.
Applied inputsubstance: Psilocybin / psilocin
Evidence modesafety boundary
Next review2026-11-26
Preselected reference valuePsilocybin / psilocinThis value is applied to the real calculator input. Adjust the remaining assumptions and verify the visible source before relying on the result.
Reference calculation

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Calculated locally. This L3 calculator does not load optional analytics; calculator inputs and result text stay on this page.

Do not infer a half-life from a similar drug

Your result
6.25%

The displayed fraction is the one-compartment equation 0.5^(elapsed ÷ half-life). FDA labeling distinguishes effective and terminal half-life and may describe active metabolites, nonlinear elimination and population variability. Review note: Verify the exact product half-life.

Medication / substancePsilocybin / psilocin
Half-life entered12 hoursUnverified general value
Elapsed time48 hours
Half-lives elapsed4
Mathematical parent-drug fraction6.25%Not a measured blood level, pharmacologic effect, safety threshold or test result
Dosing contextSingle-dose illustration
Metabolite / kinetics checkNot checkedSimple exponential decay is not enough
Intended decisionEducation only
Five half-lives60 hours · 3.125% mathematical fraction
Seven half-lives84 hours · 0.78125% mathematical fraction
Safety screenNo overdose or severe symptom selected

Read before relying

Context matters.

  • Do not use a half-life multiple to decide when to stop or repeat medicine, drive, breastfeed, undergo a procedure or assume an overdose is safe.
  • The exact formulation, dose, repeated dosing, kidney or liver function, age, interactions, active metabolites and effective versus terminal half-life can materially change exposure.
  • A predicted fraction cannot tell whether a drug test will be negative; test type, analyte, cutoff and specimen collection control the reported result.
Rule set 2.0.0

Sources & scope

Source & calculation QA reviewed

The calculation guide and this source trail show what the result means, where the rule came from and when it was last reviewed. This is source-and-calculation QA, not a claim of medical, legal, tax or other professional review; time-sensitive decisions still belong with the linked authority.

JurisdictionPharmacokinetic education — exact FDA prescribing-information half-life; never a dosing, safety or test-clearance result
Last reviewed2026-08-20
Next review due2027-02-20
Review scopeCalcSpan source & calculation QA
PrivacySensitive inputs stay local · this calculator does not load optional analytics